Beta-cell proliferation in normal and streptozotocin-treated newborn rats: site, dynamics and capacity
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چکیده
منابع مشابه
study the effects of low level laser diode on no production and healing of diabetic and cortisone acetate and normal wounded sd rats
nitric oxide (no) is a small molecule synthesized by most of mammalian cells with diverse biological activities including vasodilatation, host defense and wound healing. impaired wound healing is a common occurrence among diabetics and patients receiving glucocorticoid therapy. on the other hand the application of laser in biomedical area have been increased. thus, the current studies were desi...
15 صفحه اولBeta Cell Protective Effects of Sodium Tungstate in Streptozotocin-Induced Diabetic Rats: Glycemic Control, Blockage of Oxidative Stress and Beta Cell Histochemistry
Background: Diabetes is a major public health problem. The development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. In this study, protective effects of sodium tungstate against STZ-induced beta-cell damages were investigated. Methods: Sixty rats were divided into six groups: control, diabetic, sodium tungstate treated diabetic r...
متن کاملStereological Evaluation of Cell Proliferation following Intrarenal Injection of Platelet-rich Plasma in Gentamicin-treated Rats
Background & objectives: Nephrotoxicity is the most important side effect of gentamicin and is a concern in clinical situations. There are no therapeutic tools to prevent or palliate nephrotoxicity. Platelet-rich plasma (PRP) as a source of growth factors can be considered as a therapeutic tool. Therefore, the aim of this study was to investigate the effects of PRP on proliferation of epithel...
متن کاملGlucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.
In neonatal Wistar rats injected with streptozotocin (STZ) at birth (n0-STZ model), a recognized model of beta-cell regeneration, we investigated the capacity of early treatment with glucagon-like peptide 1 (GLP-1) or exendin-4 to promote beta-cell regeneration and thereby improve islet function in the long term, when animals become adults. To this end, n0-STZ rats were submitted to GLP-1 or ex...
متن کاملActivin A and betacellulin: effect on regeneration of pancreatic beta-cells in neonatal streptozotocin-treated rats.
Activin A and betacellulin (BTC) are thought to regulate differentiation of pancreatic beta-cells during development and regeneration of beta-cells in adults. In the present study, we used neonatal rats treated with streptozotocin (STZ) to investigate the effects of activin A and BTC on regeneration of pancreatic beta-cells. One-day-old Sprague-Dawley rats were injected with STZ (85 micro g/g) ...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1994
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s001250050221